✦ LIBER ✦

Glutathione S-transferase P1 and alpha gene variants; role in susceptibility and tumor size development of oral cancer

✍ Scribed by Mu-Kuan Chen; Hsiu-Ting Tsai; Tsung-Te Chung; Shih-Chi Su; Te-Yu Kao; Hsien-Chun Tseng; Te-Hsiung Liu; Hui-Ling Chiou; Shun-Fa Yang

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 239 KB
Volume: 32
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.21297

No coin nor oath required. For personal study only.

✦ Synopsis

Background. The aim of this study was to estimate the relationship of glutathione S-transferases (GST)P1, GSTA1, GSTM1, and GSTT1 gene polymorphisms to oral cancer risk.

Methods. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure these 4 gene polymorphisms in 274 controls and 164 oral cancer patients.

Results. Individuals with at least 1 varied G allele of GSTP1 had a 1.53-fold risk (95% confidence interval [CI] ¼ 1.01-2.31) of developing oral cancer compared with patients with wild-type A/A homozygotes. Oral cancer patients with at least 1 varied T allele of GSTA1 gene had a 0.42-fold risk (95% CI ¼ 0.18-0.95) of having a tumor size >2 cm compared with patients with C/C homozygotes.

Conclusions. The varied G allele of GSTP1 may be considered as a factor contributing to increased susceptibility, whereas the T allele of GSTA1 could be a protective factor for tumor size progression in Taiwanese with oral cancer. V

📜 SIMILAR VOLUMES

Polymorphisms of the glutathione S-trans

Polymorphisms of the glutathione S-transferase P1 gene and head and neck cancer susceptibility

✍ Michael B. Oude Ophuis; Hennie M. J. Roelofs; Piet A. van den Brandt; Wilbert H. 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 86 KB 👁 2 views

## Abstract ## Background. Factors determining the individual susceptibility to head and neck squamous cell carcinoma (HNSCC) are still largely unknown. An imbalance between enzymes involved in the toxification and detoxification of (pre)‐carcinogens closely related to HNSCC, which may appear duri

XRCC1 and glutathione-S-transferase gene

XRCC1 and glutathione-S-transferase gene polymorphisms and susceptibility to radiotherapy-related malignancies in survivors of Hodgkin disease : A report from the Childhood Cancer Survivor Study

✍ Ann C. Mertens; Pauline A. Mitby; Gretchen Radloff; Irene M. Jones; John Perente 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 103 KB 👁 1 views