𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Glutathione S-transferase polymorphisms and survival from head and neck cancer

✍ Scribed by Stacy A. Geisler; Andrew F. Olshan; Jianwen Cai; Mark Weissler; Joanna Smith; Douglas Bell

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
445 KB
Volume
27
Category
Article
ISSN
1043-3074

No coin nor oath required. For personal study only.

✦ Synopsis

Background. The purpose of this study was to evaluate the prognostic ability of polymorphisms of three genes involved in the metabolism of tobacco carcinogens (GSTT1, GSTM1, GSTP1) and one polymorphism of a DNA repair gene (XRCC1) for patients diagnosed with squamous cell carcinoma (SCC).

Methods. Cox proportional hazard models were used to estimate risk of death for a prospective cohort of 190 patients.

Results. Individuals with the GSTT1 functional genotype were twice as likely to die from any cause (hazard ratio [HR], 2.4; 95% confidence interval [CI], 1.13 -4.97) and were three times as likely to die from SCC (HR, 3.4; 95% CI, 1.33 -8.41) after adjustment for age, primary therapy, and stage of disease. The XRCC1 399 Gln genotype was predictive of disease recurrence.

Conclusions.

Our findings, from one of the first studies to examine this research question, suggest that genomic markers of carcinogen metabolism and DNA repair capability may serve as prognostic indicators of disease recurrence and death.

πŸ“œ SIMILAR VOLUMES

Polymorphisms of the glutathione S-trans
Polymorphisms of the glutathione S-transferase P1 gene and head and neck cancer susceptibility
✍ Michael B. Oude Ophuis; Hennie M. J. Roelofs; Piet A. van den Brandt; Wilbert H. πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 86 KB πŸ‘ 1 views

## Abstract ## Background. Factors determining the individual susceptibility to head and neck squamous cell carcinoma (HNSCC) are still largely unknown. An imbalance between enzymes involved in the toxification and detoxification of (pre)‐carcinogens closely related to HNSCC, which may appear duri

Glutathione S-transferase gene polymorph
Glutathione S-transferase gene polymorphisms and risk and survival of pancreatic cancer
✍ Li Jiao; Melissa L. Bondy; Manal M. Hassan; David Z. Chang; James L. Abbruzzese; πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 165 KB πŸ‘ 1 views

## Abstract ## BACKGROUND. Pancreatic cancer is a multifactorial disease with metastasis‐prone and therapy‐resistant nature. The authors hypothesized that genetic variants of glutathione S‐transferase (GST) affect detoxification of carcinogens and anticancer agents in the human pancreas and, thus,

Glutathione-S-transferase polymorphisms
Glutathione-S-transferase polymorphisms and risk of squamous-cell carcinoma of the head and neck
✍ Lie Cheng; Erich M. Sturgis; Susan A. Eicher; David Char; Margaret R. Spitz; Qin πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 French βš– 106 KB πŸ‘ 2 views

Differences in genetic susceptibility to tobacco-induced carcinogenesis appear to modulate an individual's risk of squamous-cell carcinoma of the head and neck (SCCHN). Risk for SCCHN may be associated with the null alleles of the carcinogen-metabolizing genes glutathione-S-transferase (GST) T1 and

Meta-analysis of glutathione S-transfera
Meta-analysis of glutathione S-transferase M1 genotype and risk toward head and neck cancer
✍ Chandra B. Tripathy; Nilanjan Roy πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 132 KB πŸ‘ 1 views

Background. We sought to evaluate the estimated risk of GSTM1 null genotype and squamous cell carcinoma of the head and neck (SCCHN). Methods. The studies done so far for GSTM1 null genotype as a risk factor associated with head and neck cancer are not conclusive and have shown conflicting results.

Association between a glutathione S-tran
Association between a glutathione S-transferase A1 promoter polymorphism and survival after breast cancer treatment
✍ Carol Sweeney; Christine B. Ambrosone; Lija Joseph; Angie Stone; Laura F. Hutchi πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 French βš– 82 KB

## Abstract Glutathione __S__‐transferase (GST) enzymes detoxify chemotherapeutic drugs, and several studies have reported differences in survival for cancer patients who have variant genotypes for GSTP1, GSTM1 or GSTT1 enzymes. A recently described polymorphism alters hepatic expression of GSTA1,