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Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells

โœ Scribed by Himburg, Heather A; Muramoto, Garrett G; Daher, Pamela; Meadows, Sarah K; Russell, J Lauren; Doan, Phuong; Chi, Jen-Tsan; Salter, Alice B; Lento, William E; Reya, Tannishtha


Book ID
109926272
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
1021 KB
Volume
16
Category
Article
ISSN
1078-8956

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In vivo, stem cell factor (SCF) exists in both a bound and soluble isoform. It is believed that the bound form is more potent and fundamentally required for the maintenance of hematopoietic stem cells (HSCs). This theory is supported by the observation that steel-Dickie mice lacking the bound isofor