Hematopoietic stem cells in the intact and regenerating adult mouse liver
✍ Scribed by N. G. Khrushchov; V. M. Faktor; I. V. Uryvaeva; É. V. Chernyshova
- Publisher
- Springer US
- Year
- 1977
- Tongue
- English
- Weight
- 254 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0007-4888
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Previous studies have identified novel lymphoid phenotypes in the adult human liver and provided evidence to suggest that lymphoid differentiation can occur locally in this organ. The aim of this study was to examine the adult human liver for the presence of hematopoietic stem cells that may provide
## Abstract Cells from regenerating mouse liver removed 2–25 days post 68% hepatic resection have been assayed for in vitro colony forming capacity in soft agar (CFU‐C), proliferative capacity in liquid culture, and in vivo spleen colony forming capacity (CFU‐S). These studies demonstrated low con
Colony-forming cells (CFU), which have the general properties of hemopoietic "stem" cells, appear to be augmented in the mouse fetal liver from 12-18 days gestation and then decrease in the newborn. This finding suggests that few, if any, hemopoietic "stem" cells remain in the adult liver, an organ