Development, expansion and maturation of hematopoietic stem cells in mouse embryo
β Scribed by Atsushi Miyajima; Ken-ichi Minehata; Masaki Takeuchi
- Publisher
- Carden Jennings Publishing
- Year
- 2002
- Tongue
- English
- Weight
- 215 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0925-5710
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In vivo, stem cell factor (SCF) exists in both a bound and soluble isoform. It is believed that the bound form is more potent and fundamentally required for the maintenance of hematopoietic stem cells (HSCs). This theory is supported by the observation that steel-Dickie mice lacking the bound isofor
## Abstract Embryonic stem (ES) cells have been shown to differentiate in vitro into a wide variety of cell types having significant potential for tissue regeneration. Therefore, the operational conditions for the ex vivo expansion and differentiation should be optimized for largeβscale cultures. T