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Platelet monoamine oxidase B activity in Parkinson's disease: A re-evaluation

✍ Scribed by J. Jarman; V. Glover; M. Sandler; N. Turjanski; G. Stern


Publisher
Springer
Year
1993
Tongue
English
Weight
234 KB
Volume
5
Category
Article
ISSN
1435-1463

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Monoamine oxidase B (MAO-B) is implicated in the cause of Parkinson's disease (PD) because of its role in metabolizing the neurotoxin l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine, and forming H,02 during dopamine metabolism. Altered MAO-B activity has been observed in PD platelets. Polymerase chain

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## Abstract A dose‐ranging study of selegiline was performed in patients with Parkinson's disease to determine the minimal dosage of the drug able to inhibit β‰₯95% of platelet monoamine oxidase (MAO) activity. Different doses of selegiline (5 or 10 mg daily, 10 or 20 mg weekly) were studied in four