Platelet monoamine oxidase B activity in Parkinson's disease: A re-evaluation
β Scribed by J. Jarman; V. Glover; M. Sandler; N. Turjanski; G. Stern
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 234 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1435-1463
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Monoamine oxidase B (MAO-B) is implicated in the cause of Parkinson's disease (PD) because of its role in metabolizing the neurotoxin l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine, and forming H,02 during dopamine metabolism. Altered MAO-B activity has been observed in PD platelets. Polymerase chain
## Abstract A doseβranging study of selegiline was performed in patients with Parkinson's disease to determine the minimal dosage of the drug able to inhibit β₯95% of platelet monoamine oxidase (MAO) activity. Different doses of selegiline (5 or 10 mg daily, 10 or 20 mg weekly) were studied in four