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Platelet Aggregation Inhibiting and Anticoagulant Effects of Oligoamines, XXII: Bisoxazol-, Bisimidazol-, Bisthiazol- and Oligo-1,2,4-thiadiazolimines

✍ Scribed by Klaus Rehse; Antje Martens

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
567 KB
Volume
326
Category
Article
ISSN
0365-6233

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✦ Synopsis

Abstract

One mesoionic 4,4′‐propylene‐bis‐oxazol‐5‐imine (5), two 2,2′‐m‐phenylene‐bis‐imidazol‐4‐imines (9a,b), five 4,4′‐benzene‐bis‐(and tris)‐thiazol‐2‐amines (13a,b, 14a‐c) and 14 3,3′‐benzene‐bis‐(and tris)‐1,2,4‐thiadiazolimines (18a‐o) were synthesized and assayed for their antiplatelet and anticoagulant activities. The most potent compound was the tris‐thiadiazole derivative 18m which inhibited the aggregation of platelets induced by collagen at a concentration of 10 μmol/L by 50 percent (Born‐test). No anticoagulant effects (Quick‐test) were observed up to 400 μmol/L. In the thiazolamine series combined antiplatelet and anticoagulant activities were seen.

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