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Platelet Aggregation Inhibiting and Anticoagulant Effects of Oligoamines, XX: 4,4′,4″-(1,3,5)-Benzene-tris-sydnone Imines

✍ Scribed by Klaus Rehse; Antje Martens

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
338 KB
Volume
326
Category
Article
ISSN
0365-6233

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✦ Synopsis

Abstract

The synthesis of ten tris‐sydnone imine derivatives, unknown up to now, is described. All compounds are alkyl or arylalkyl substituted in 3‐position of the sydnone imine. The most powerful agent was the 3‐propyl derivative 6c. It inhibits the aggregation of human platelets induced by collagen in a concentration of 1 γmol/L half maximally. Its N‐ethoxycarbonyl derivative 7c, which was designed as a prodrug, showed only small antithrombotic effects in rats. The reason for this low degree of activity is discussed.

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Platelet Aggregation Inhibiting and Anti
Platelet Aggregation Inhibiting and Anticoagulant Effects of Oligoamines, XXII: Bisoxazol-, Bisimidazol-, Bisthiazol- and Oligo-1,2,4-thiadiazolimines
✍ Klaus Rehse; Antje Martens 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 567 KB

## Abstract One mesoionic 4,4′‐propylene‐bis‐oxazol‐5‐imine (5), two 2,2′‐__m__‐phenylene‐bis‐imidazol‐4‐imines (9a,b), five 4,4′‐benzene‐bis‐(and tris)‐thiazol‐2‐amines (13a,b, 14a‐c) and 14 3,3′‐benzene‐bis‐(and tris)‐1,2,4‐thiadiazolimines (18a‐o) were synthesized and assayed for their antiplate