Platelet Aggregation Inhibiting and Anticoagulant Effects of Oligoamines, XIX: 4,4′-Phenylene-bis-sydnone Imines
✍ Scribed by Klaus Rehse; Michael Kämpfe; Antje Martens
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 384 KB
- Volume
- 326
- Category
- Article
- ISSN
- 0365-6233
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## Abstract The synthesis of ten tris‐sydnone imine derivatives, unknown up to now, is described. All compounds are alkyl or arylalkyl substituted in 3‐position of the sydnone imine. The most powerful agent was the 3‐propyl derivative 6c. It inhibits the aggregation of human platelets induced by co
Selected synthetic oligoamines were able to inhibit (ICso) the growth of leukemic L 1210cells in concentrations between4-10 J.1rnollL TIle essential structural features were at least two basic nitrogen functions in suitable distance, substituted with arylalkyl or alkyl groups. TIle favorable chain l
Oligosydnone imines are strongly bound to albumine (a < 1%) in pure water. In saline, however, this effect is abolished (a -80%). 4,4'-Propy-\*\*) Pan of the PhD thesis D. Piechocki, Fu Berlin, 1992