Selected synthetic oligoamines were able to inhibit (ICso) the growth of leukemic L 1210cells in concentrations between4-10 J.1rnollL TIle essential structural features were at least two basic nitrogen functions in suitable distance, substituted with arylalkyl or alkyl groups. TIle favorable chain l
Platelet Aggregation Inhibiting and Anticoagulant Effects of Oligoamines, XV: Antithrombotic Effect of Selected Oligoamines in Rats
✍ Scribed by Klaus Rehse; Andreas Kesselhut; Volkmar Schein; Michael Kämpfe; Bettina Rose; Eberhard Unsöld
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 454 KB
- Volume
- 324
- Category
- Article
- ISSN
- 0365-6233
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Oligosydnone imines are strongly bound to albumine (a < 1%) in pure water. In saline, however, this effect is abolished (a -80%). 4,4'-Propy-\*\*) Pan of the PhD thesis D. Piechocki, Fu Berlin, 1992
## Abstract The synthesis of ten tris‐sydnone imine derivatives, unknown up to now, is described. All compounds are alkyl or arylalkyl substituted in 3‐position of the sydnone imine. The most powerful agent was the 3‐propyl derivative 6c. It inhibits the aggregation of human platelets induced by co