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PIK3CA Mutation Status in Japanese Esophageal Squamous Cell Carcinoma

✍ Scribed by Ryota Mori; Hideyuki Ishiguro; Masahiro Kimura; Akira Mitsui; Hidefumi Sasaki; Keisuke Tomoda; Yoichiro Mori; Ryo Ogawa; Takeyasu Katada; Osamu Kawano; Koshiro Harada; Yoshitaka Fujii; Yoshiyuki Kuwabara

Book ID: 116703421
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 957 KB
Volume: 145
Category: Article
ISSN: 0022-4804
DOI: 10.1016/j.jss.2007.03.044

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PIK3CA belongs to the phosphatidylinositol 3-kinases (PI3Ks) family, which play an important role in proliferation, adherence, transformation and cell survival through the PI3K/AKT signaling pathway. Somatic activating mutations of this gene have recently been detected in several types of cancers. I