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PIK3CA mutations in nasopharyngeal carcinoma

✍ Scribed by Yvonne Yan-Yan Or; Angela Bik-Yu Hui; Ka-Fai To; Cleo Nga-Yee Lam; Kwok-Wai Lo


Publisher
John Wiley and Sons
Year
2005
Tongue
French
Weight
421 KB
Volume
118
Category
Article
ISSN
0020-7136

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PIK3CA belongs to the phosphatidylinositol 3-kinases (PI3Ks) family, which play an important role in proliferation, adherence, transformation and cell survival through the PI3K/AKT signaling pathway. Somatic activating mutations of this gene have recently been detected in several types of cancers. I

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