Rare PIK3CA hotspot mutations in carcino
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Marc-Oliver Riener; Marion Bawohl; Pierre-Alain Clavien; Wolfram Jochum
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Article
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2008
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John Wiley and Sons
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English
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## Abstract Somatic mutations of the __PIK3CA__ gene, which encodes the p110Ξ± catalytic subunit of phosphatidylinositol 3βkinase (PI3K), are frequent in various cancer types. The majority of mutations cluster at hotspots within exons 9 and 20, which encode the helical and kinase domains of p110Ξ±. _