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PIK3CA gene mutations in breast carcinoma in Malaysian patients

✍ Scribed by Vincent Ching-Shian Leong; Mohd Faizal Jabal; Pooi Pooi Leong; Maizaton Atmadini Abdullah; Yunus Alif Gul; Heng Fong Seow

Book ID
113513409
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
507 KB
Volume
187
Category
Article
ISSN
0165-4608

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PIK3CA belongs to the phosphatidylinositol 3-kinases (PI3Ks) family, which play an important role in proliferation, adherence, transformation and cell survival through the PI3K/AKT signaling pathway. Somatic activating mutations of this gene have recently been detected in several types of cancers. I