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PIK3CA-AKT pathway mutations in micropapillary breast carcinoma

✍ Scribed by Flatley, Ellen; Ang, Daphne; Warrick, Andrea; Beadling, Carol; Corless, Christopher L.; Troxell, Megan L.


Book ID
121888290
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
927 KB
Volume
44
Category
Article
ISSN
1532-8392

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PIK3CA belongs to the phosphatidylinositol 3-kinases (PI3Ks) family, which play an important role in proliferation, adherence, transformation and cell survival through the PI3K/AKT signaling pathway. Somatic activating mutations of this gene have recently been detected in several types of cancers. I