✦ LIBER ✦

Photogenerated Quinone Methides as Protein Affinity Labeling Reagents

✍ Scribed by Jiangsong Jiang; Dexing Zeng; Shuwei Li

Book ID: 101819665
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 356 KB
Volume: 10
Category: Article
ISSN: 1439-4227
DOI: 10.1002/cbic.200800700

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Highly specific protein labeling: Photogenerated quinine methides (QMs) can act as highly specific light‐controllable protein affinity labeling reagents, broadening their applications to the study of protein–ligand and protein–protein interactions. The reactions between QMs and nucleophiles are less heterogeneous than those of other photogenerated active intermediates such as carbenes and nitrenes, making it easier to identify labeled species.magnified image

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