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4-Benchrotrenyl Pyrylium Salts as Protein Organometallic Labelling Reagents

✍ Scribed by Bertrand Caro; Françoise Le Guen-Robin; Michèle Salmain; Gérard Jaouen

Book ID: 104209763
Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 175 KB
Volume: 56
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(99)00947-3

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✦ Synopsis

Pyrylium ions are useful reagents to selectively modify the amino group of protein lysine residues. This property was exploited here to label proteins with chromium tricarbonyl complexes in the form of 4-benchrotrenyl pyridinium ions. Kinetic studies of the reaction of a series of benchrotrenyl pyrylium salts with water and n-butylamine were performed and revealed that the overall reactivity of these compounds was highly dependent on their substitution pattern. These compounds could find application in protein X-ray crystallography.

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