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Suitability of sulfur labelling reagent (Amersham) as an in vitro protein radiolabelling reagent for two-dimensional electrophoresis

✍ Scribed by Dr. Thierry Rabilloud; HéLène Therre


Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
335 KB
Volume
7
Category
Article
ISSN
0173-0835

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✦ Synopsis


Suitability of sulfur labelling reagent (Amersham) as an in vitro protein radiolabelling reagent for two-dimensional electrophoresis

This report describes a method of in vitro labelling ofproteins designed for subsequent analysis of the sample by two-dimensional electrophoresis. As much as lo6 cpm can be incorporated in 5 pg of proteins. As the reagent reacts with the amino groups, virtually all the proteins are labelled. Thus, this method is far more sensitive than silver staining and may prove useful when extremely low amounts of sample are to be analy sed.