## Abstract ## BACKGROUND Up to 5% of patients with chronic myelogenous leukemia (CML) do not have the Philadelphia (Ph) translocation t(9;22)(q34;q11) or a __bcr__/__abl__ molecular rearrangement. Although the diagnostic criteria of this entity are still under debate, there is general agreement t
Philadelphia Chromosome-positive Chronic Myelogenous Leukemia with Deleted Fusion of BCR and ABL Genes
β Scribed by Ohyashiki, Kazuma ;Ohyashiki, Junko H. ;Iwabuchi, Hirotaka ;Tauchi, Tetsuzo ;Iwabuchi, Atsuhiro ;Toyama, Keisuke
- Book ID
- 108578989
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1990
- Tongue
- English
- Weight
- 698 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0910-5050
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We have isolated the 3Π BCR breakpoint junction of a complex BCR-ABL1 rearrangement found in leukemic cells with a cytogenetically normal karyotype, and the corresponding germline fragment that spanned the 3Π BCR recombination site. Fluorescence in situ hybridization localized the 3Π BCR recombinati
A reciprocal translocation, t( I022)(q2Z;q I I), resulting in a masked Ph chromosome was identified in a patient diagnosed with chronic myeloid leukemia (CML). Both homologs of chromosome 9 were of the normal pattern. Two signals for the ABL probe, both of them hybridized to chromosome 9, were demon