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Deletion of the 5′ abl region in Philadelphia chromosome-positive chronic myeloid leukemia

✍ Scribed by Morel, F; Ka, C; Le Bris, M-J; Herry, A; Morice, P; Bourquard, P; Abgrall, J F; Berthou, C; De Braekeleer, M

Book ID
110055371
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
90 KB
Volume
17
Category
Article
ISSN
0887-6924

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We have isolated the 3Ј BCR breakpoint junction of a complex BCR-ABL1 rearrangement found in leukemic cells with a cytogenetically normal karyotype, and the corresponding germline fragment that spanned the 3Ј BCR recombination site. Fluorescence in situ hybridization localized the 3Ј BCR recombinati