A 9-phenylfluoren-9-yl based linker for the immobilization of nitrogen and oxygen nucleophiles is described Improved acid stability compared to the common trityl linker is demonstrated by a quantitative method for analysis of loading. This new linker is used for the synthesis of a peptide alcohol in
PhFl polystyrene: A new resin for solid phase organic synthesis
β Scribed by Konrad H. Bleicher; James R. Wareing
- Book ID
- 108386814
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 252 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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Polystyrene resins containing flexible tetrahydrofuran derived cross-linkers are presented. These cross-linkers were designed to render the resins more 'organic solvent-like' and thus impart increased swelling/solvation characteristics in the resins with regard to common solvents used in solid-phase