An improved and straightforward synthesis of (4-ethenylphenyl)diphenyl methanol is described. This monomer was used in the preparation of trityl functionalized polystyrene containing a flexible tetrahydrofuran cross-linker, giving rise to a suitable support for solid-phase organic synthesis.
New supports for solid-phase organic synthesis: development of polystyrene resins containing tetrahydrofuran derived cross-linkers
β Scribed by Patrick H. Toy; Kim D. Janda
- Book ID
- 104262034
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 211 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
Polystyrene resins containing flexible tetrahydrofuran derived cross-linkers are presented. These cross-linkers were designed to render the resins more 'organic solvent-like' and thus impart increased swelling/solvation characteristics in the resins with regard to common solvents used in solid-phase organic synthesis.
π SIMILAR VOLUMES
A new aminoethyl-polystyrene linker, stable at low concentrations of TFA, has been developed for the solid phase synthesis of peptide amides. The described linker is stable under conditions which remove Bu(t) protecting groups (30-50% TFA in DCM) and the desired product can be finally cleaved off th