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Phenobarbital pretreatment in vivo and in vitro and the effect of hepatotoxicity of d-galactosamine in rat hepatocytes in culture

✍ Scribed by M.J.M. Toussaint; M.M.L. De Wit; B.J. Blaauboer; H. Nederbragt

Book ID
116152981
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
611 KB
Volume
8
Category
Article
ISSN
0887-2333

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Effect of phenobarbital pretreatment on
Effect of phenobarbital pretreatment on in vitro enzyme kinetics and in vivo biotransformation of benzene in the rat
✍ I. Gut πŸ“‚ Article πŸ“… 1976 πŸ› Springer-Verlag 🌐 English βš– 704 KB

Phenobarbital pretreatment (50 mg/kg/day for 3 days orally) of male Wistar rats increased Vmax of benzene in vitro hepatic microsomal biotransformation about 6-fold without changing Km. However, benzene blood levels after oral, intraperitoneal, or subcutaneous benzene administration (3-3.5 mmoles/kg