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Galactosamine hepatotoxicity: Effect of galactosamine on glutathione resynthesis in rat primary hepatocyte cultures

โœ Scribed by JoEllyn M. McMillan; David J. Jollow


Book ID
113207851
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
856 KB
Volume
115
Category
Article
ISSN
0041-008X

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We have shown that nitric oxide production is dramatically decreased in rat primary hepatocyte cultures exposed to galactosamine. Cotreatment of the cells with uridine, which is known to prevent cytotoxicity, was found to also attenuate NO loss. In the present study, two possible mechanisms for the