Phase I/II study of recombinant interferon α and γ in advanced progressive renal-cell carcinoma
✍ Scribed by Pieter H. M. de Mulder; Frans M. J. Debruyne; Mart P. H. Franssen; Arno D. H. Geboers; Simon Strijk; Ad G. M. Reintjes; Wim H. Doesburg; Otto Damsma
- Publisher
- Springer-Verlag
- Year
- 1990
- Tongue
- English
- Weight
- 585 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0340-7004
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Eighteen patients with advanced non-smallcell lung cancer (NSCLC) received recombinant beta interferon, 90 million units three times weekly. No complete or partial responses were seen. Five patients had stable disease for several months. Most patients experienced some toxicity, most commonly fever a
## BACKGROUND. Renal cell carcinoma is a common neoplasm that is often refractory to treatment. It is occasionally responsive to immunoniodulating agents including interferon-a, which enhances the effects of 5-fluorouracil upon cells. Combinations of these two drugs have been most frequently tested