A phase II trial of interferon alpha-2A plus fluorouracil in advanced renal cell carcinoma
โ Scribed by Brian R. Murphy; Susan M. Rynard; Lawrence H. Einhorn; Patrick J. Loehrer
- Publisher
- Springer US
- Year
- 1992
- Tongue
- English
- Weight
- 499 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0167-6997
No coin nor oath required. For personal study only.
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## BACKGROUND. Renal cell carcinoma is a common neoplasm that is often refractory to treatment. It is occasionally responsive to immunoniodulating agents including interferon-a, which enhances the effects of 5-fluorouracil upon cells. Combinations of these two drugs have been most frequently tested
A Phase I1 clinical trial of the combination of 5-fluorouracil (5-FU) and recombinant alpha-2a-interferon (a-2a-IFN) was conducted in 44 patients. Patients had not received chemotherapy previously and had measurable metastatic gastric carcinoma. 5-FU was administered as a continuous infusion at a do