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A phase II trial of interferon-α and 5-fluorouracil in patients with advanced renal cell carcinoma: A Southwest Oncology Group study

✍ Scribed by Laurence Elias; Brent A. Blumenstein; Julie Kish; Robert C. Flanigan; James L. Wade; Bruce A. Lowe; John Wendall Goodwin; E. David Crawford

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
355 KB
Volume
78
Category
Article
ISSN
0008-543X

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✦ Synopsis

BACKGROUND.

Renal cell carcinoma is a common neoplasm that is often refractory to treatment. It is occasionally responsive to immunoniodulating agents including interferon-a, which enhances the effects of 5-fluorouracil upon cells. Combinations of these two drugs have been most frequently tested in patients with gastrointestinal cancers, with some promising results. Because interferon-a has activity for renal cell carcinoma, a trial of this combination in patients with this malignancy was undertaken.

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