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Phase II trial of tamoxifen, etoposide, mitoxantrone, and cisplatin in patients with metastatic breast carcinoma

✍ Scribed by Suzanne D. Conzen; Peter A. Kaufman; Christine Arvizu; Paul LeMarbre; L. Herbert Maurer; Leila A. Mott; Letha E. Mills

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
554 KB
Volume
78
Category
Article
ISSN
0008-543X

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✦ Synopsis

BACKGROUND.

Based on previous data demonstrating a potentially synergistic interaction between tamoxifen and cisplatin in metastatic melanoma therapy, a Phase I1 study was performed to assess the activity of tamoxifen, etoposide, mitoxantrone, and cisplatin (TEMP) in patients with metastatic breast carcinoma.

METHODS.

Forty-six patients with metastatic breast carcinoma were treated with tamoxifen, 10 mg orally, twice a day for 28 days; etoposide, 100 mglm', on Days 1-3; mitoxantrone, 10 mgfm', on Day 1; and cisplatin, 30 mg/m2, on Days 1 and 2. Forty-four patients (7 with bone-only disease) were evaluable for response and toxicity after at least 1 cycle of therapy. All patients had previously received doxorubicin-containing regimens in either the adjuvant or metastatic setting.

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