## Abstract ## Objective. We assessed the response rate and the toxicity of cisplatin plus vinorelbine in patients with this condition. ## Patients and Method. Fortyβtwo patients were included. Therapy consisted of cisplatin, 100 mg/m^2^ on day 1, and vinorelbine, 25 mg/m^2^ on days 1 and 8, giv
Phase II trial of irinotecan plus cisplatin in patients with recurrent or metastatic squamous carcinoma of the head and neck
β Scribed by Jill Gilbert; Anthony Cmelak; Yu Shyr; James Netterville; Brian B. Burkey; Robert J. Sinard; Wendall G. Yarbrough; Christine H. Chung; Joseph M. Aulino; Barbara A. Murphy
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 86 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0008-543X
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π SIMILAR VOLUMES
Forty-two patients with recurrent or metastatic squamous cell carcinoma of the head and neck were treated with vinblastine, bleomycin, and cisplatin. All patients had received prior surgery, radiation or chemotherapy and all had measurable disease. Forty-five percent of the patients responded with a
## BACKGROUND. The combination of cisplatin and 5-flurouracil (5-FU) is considered standard therapy for patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN). Paclitaxel has exhibited single-agent activity in patients with this disease. The authors conducted thi