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Phase I trial of the novel platinum analog ZD0473 in combination with gemcitabine in patients with advanced cancer

✍ Scribed by P. O'Dwyer; J. Stevenson; M. Redlinger; W. Sun; B. Giantonio; S. Hahn; K. Algazy; M. Burnite; M. Koehler

Book ID
117658114
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
182 KB
Volume
37
Category
Article
ISSN
0959-8049

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## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and dose‐limiting toxicities (DLTs) of bortezomib in combi