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A phase I trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone in combination with gemcitabine for patients with advanced cancer

✍ Scribed by Yun Yen; Kim Margolin; James Doroshow; Mayer Fishman; Bonny Johnson; Caroline Clairmont; Dan Sullivan; Mario Sznol

Publisher
Springer
Year
2004
Tongue
English
Weight
233 KB
Volume
54
Category
Article
ISSN
0344-5704

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## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and dose‐limiting toxicities (DLTs) of bortezomib in combi