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A phase I, dose escalation trial of ZD0473, a novel platinum analogue, in combination with gemcitabine

✍ Scribed by KeithT. Flaherty; JamesP. Stevenson; Maryann Redlinger; KennethM. Algazy; Bruce Giantonio; PeterJ. O’Dwyer

Publisher: Springer
Year: 2004
Tongue: English
Weight: 172 KB
Volume: 53
Category: Article
ISSN: 0344-5704
DOI: 10.1007/s00280-003-0754-1

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## Abstract ## BACKGROUND Platinum‐based regimens have improved response rates and survival in patients with advanced transitional cell carcinoma (TCC) of the urothelial tract. However, the toxicities of platinum‐based chemotherapy are considerable. Regimens with reduced toxicity that are applicab