Pharmacology of a new non-steroidal anti-inflammatory agent 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one (W-2395)
โ Scribed by R.D. Sofia; W. Diamantis; R. Gordon; M. Kletzkin; F.M. Berger; J. Edelson; H. Singer; J.F. Douglas
- Book ID
- 118321435
- Publisher
- Elsevier Science
- Year
- 1974
- Tongue
- English
- Weight
- 810 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0014-2999
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The absorption and metabolic fate of 7-chloro-3,3adihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)( 1,3)-benzoxazin-9-one (I) was studied in rats, dogs, and humans. Orally administered I was readily absorbed by all species. In the rat, orally administered I was converted to its metabolite, 5-chlorosalicylic
A simple, rapid, and quantitative NMR method was developed for the determination of the ratio of the diastereoisomers present in 7-chloro-3,3a-dihydro-2-methyl-2H, 9H-isoxazolo(3,2-b)(1,3)benzoxazin-9-one (I). Deuterated tris(1,1,1,2,2,3,3heptafluoro-7,7-dimethyl-4,6-octanedionato)europium I11 shift