Pharmacological characterization of the neonatally sensitized rabbit model and effects of a novel phosphodiesterase (PDE) 4 inhibitor
โ Scribed by Neil Gozzard; Bernadette Hughes; Graham Warrellow; Gerry Higgs
- Book ID
- 118110907
- Publisher
- Pharmaceutical Press
- Year
- 1998
- Tongue
- English
- Weight
- 102 KB
- Volume
- 50
- Category
- Article
- ISSN
- 2042-7158
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Background Nitrergic nerves and endothelial cells release nitric oxide (NO) in the corpus cavernosum (CC), a key mediator that stimulates soluble guanylyl cyclase to increase cGMP levels and cause penile erection. Phosphodiesterase 5 (PDE5) inhibitors, such as sildenafil, prolong NO effects by
## Abstract A simple, highโyielding synthesis of dibutyl[^14^C]formamide ([^14^C]DBF; **1**) from ^14^CO~2~ was developed (__Schemeโ 1__): reaction of LiBEt~3~H and ^14^CO~2~ followed by aqueous workup gave H^14^CO~2~H in high yield. Conversion of the [^14^C]formic acid to **1** was effected by a st