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Pharmacologic antagonism of thromboxane A2 receptors by trimetoquinol analogs in vitro and in vivo

โœ Scribed by Yangmee Shin; Karl J. Romstedt; Kathrine Doyle; Marc W. Harrold; Mark A. Gerhardt; Duane D. Miller; Popat N. Patil; Dennis R. Feller


Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
604 KB
Volume
3
Category
Article
ISSN
0899-0042

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Picotamide (G 137), a new non prostanoid inhibitor of in vitro arachidonic acid induced platelet aggregation, has been further characterized in in vitro and ex vivo studies. When whole blood was activated with collagen in the presence of picotamide 5 x 10(-4) M, thromboxane B2 production was decreas