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In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: An overview

✍ Scribed by J. P. Famaey

Publisher
SP Birkhäuser Verlag Basel
Year
1997
Tongue
English
Weight
130 KB
Volume
46
Category
Article
ISSN
1420-908X

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## Abstract Cholera toxin irreversibly activates a 43‐kDa guanosine triphosphate (GTP)‐binding protein by adenosine diphosphate ribosylation, resulting in activation of adenylate cyclase and increased intracellular levels of cyclic adenosine monophosphate (cAMP). Because increases in intracellular