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Pharmacokinetics, safety and immunomodulatory effects of human recombinant interleukin-1 receptor antagonist in healthy humans

✍ Scribed by Granowitz, Eric V.; Porat, Reuven; Mier, James W.; Pribble, John P.; Stiles, David M.; Bloedow, Duane C.; Catalano, Michael A.; Wolff, Sheldon M.; Dinarello, Charles A.


Book ID
123494841
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
877 KB
Volume
4
Category
Article
ISSN
1043-4666

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Effect of benzyl alcohol on recombinant
✍ John R. Alford; Andrew C. Fowler; Deborah S. Wuttke; Bruce A. Kerwin; Ramil F. L πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 505 KB

Benzyl alcohol, a preservative commonly added to multidose therapeutic protein formulations, can accelerate aggregation of recombinant human interleukin-1 receptor antagonist (rhIL-1ra). To investigate the interactions between benzyl alcohol and rhIL-1ra, we used nuclear magnetic resonance to observ