Pharmacokinetics of YM466, a new factor Xa inhibitor, in rats and dogs
β Scribed by Yuji Mano; Takashi Usui; Hidetaka Kamimura
- Publisher
- Springer-Verlag
- Year
- 2004
- Tongue
- English
- Weight
- 972 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0378-7966
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## Abstract The antithrombotic effects of YM466, a synthetic direct inhibitor of human factor Xa (FXa), were evaluated in an arterioβvenous shunt thrombosis model in squirrel monkeys. YM466 significantly inhibited thrombus formation after continuous IV zx infusion at doses of 3β30 Β΅g/kg/h. Although
## Abstract The pharmacokinetics of a series of novel cyclic, nonβpeptide inhibitors of HIV protease were studied in rats or dogs after intravenous and oral administration. Six symmetrically substituted cyclic urea compounds (XK234, XM311, XM320, XM321, XM323, and XM412), which effectively inhibite