A pharmacokinetic evaluation of HIV protease inhibitors, cyclic ureas, in rats and dogs

✍ Scribed by Y. Nancy Wong; Deborah L. Burcham; Philip L. Saxton; Susan Erickson-Viitanen; Mary F. Grubb; Check Y. Quon; Shiew-Mei Huang

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 425 KB
• Volume: 15
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bdd.2510150702

✦ Synopsis

Abstract

The pharmacokinetics of a series of novel cyclic, non‐peptide inhibitors of HIV protease were studied in rats or dogs after intravenous and oral administration. Six symmetrically substituted cyclic urea compounds (XK234, XM311, XM320, XM321, XM323, and XM412), which effectively inhibited HIV virus replication, with IC~90~, values of 0.03–1.0 μM (0.017–0.76 μg mL^−1^), were evaluated. Plasma concentrations were measured in rats and dogs using specific and sensitive HPLC methods. In rats, the maximum plasma concentrations of 0.21–1.88 μg mL^−1^ were detected within 1 h of oral administration of 10 mg kg^−1^ of the compounds. The elimination half‐lives ranged from 1.25 to 3.3 h in rats and the absolute oral bioavailability ranged from 18 to 100%. In dogs, the maximum plasma concentration and absolute oral bioavailability were 4.37 μg mL^−1^ and 48%, 1.07 μg mL^−1^ and 16%, and 1.48 mg mL^−1^ and 38% for XK234, XM311, and XM323, respectively. The data demonstrated that the maximum plasma concentrations of these cyclic ureas were several times higher than the IC~90~ for inhibition of viral replication after single doses of 10 mg kg^−1^ in rats and dogs. With this combination of high potency against virus replication and good oral bioavailability, these cyclic ureas represent a new class of compounds that are suitable for development as therapeutic agents for the treatment of HIV‐associated diseases.