✦ LIBER ✦

Pharmacokinetic evaluation of noreximide in rats

✍ Scribed by Heinrich P. Koch; Gertrude Pischek; Margarete Holzbecher; Wolfgang A. Ritschel

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 296 KB
Volume: 2
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510020305

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The pharmacokinetics of noreximide in the rat after i.v., p.o., and i.p. administration was studied. The biologic half‐life of approximately 8 h was found almost the same for all three routes. Upon p.o. administration the fraction of drug absorbed is 85 per cent, and the peak concentration in the blood is reached within approximately 4.5 h. Additional pharmaco‐kinetic parameters are listed.

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