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Metabolism, pharmacokinetics and pharmacodynamics of the factor Xa inhibitor apixaban in rabbits

✍ Scribed by Donglu Zhang; Kan He; Nirmala Raghavan; Lifei Wang; Earl J. Crain; Bing He; Baomin Xin; Joseph M. Luettgen; Pancras C. Wong

Publisher: Springer US
Year: 2009
Tongue: English
Weight: 784 KB
Volume: 29
Category: Article
ISSN: 0929-5305
DOI: 10.1007/s11239-009-0401-8

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## Abstract Apixaban is a potent inhibitor of blood coagulation Factor Xa in the late stages of development. [^14^C]apixaban was synthesized with the 14C label in the two different lactam ring systems within the molecule for various __in vitro__ and __in vivo__ metabolism studies. A nine‐step synth