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Pharmacokinetics of nalidixic acid in man: Hydroxylation and glucuronidation

โœ Scribed by Vree, T. B. ;Wijnands, W. J. A. ;Baars, A. M. ;Hekster, Y. A.


Publisher
Springer
Year
1988
Tongue
Dutch
Weight
539 KB
Volume
10
Category
Article
ISSN
1573-739X

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Pharmacokinetic model for nalidixic acid
โœ G. A. Portmann; E. W. McChesney; H. Stander; W. E. Moore ๐Ÿ“‚ Article ๐Ÿ“… 1966 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 532 KB

a two-step protonation. As a check of the method, the pKa of o-iodobenzoic acid was determined concurrently, yielding the value of -7.4 which is in good agreement with previously published data ( 12). A first protonation of compound I could lead to structures Ib, Id, Ic, or If; loss of water from I