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Probenecid inhibits the renal clearance and renal glucuronidation of nalidixic acid

✍ Scribed by Vree, T. B. ;Biggelaar-Martea, M. ;Ewijk-Beneken Kolmer, E. W. J. ;Hekster, Y. A.

Publisher
Springer
Year
1993
Tongue
Dutch
Weight
426 KB
Volume
15
Category
Article
ISSN
1573-739X

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Plasma kinetics and renal excretion of iodopyracet (3\*0g, adminstered i.v.) with and without concomitant administration of probenecid were studied in the beagle dog. Pharmacokinetic analysis revealed that tubular secretion is the predominant route of excretion, and that secretion is inhibited by pr