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Pharmacokinetic model for nalidixic acid in man III. Effect of repeated oral dosage

✍ Scribed by E. W. McChesney; G. A. Portmann; R. F. Koss

Publisher: John Wiley and Sons
Year: 1967
Tongue: English
Weight: 584 KB
Volume: 56
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600560510

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a two-step protonation. As a check of the method, the pKa of o-iodobenzoic acid was determined concurrently, yielding the value of -7.4 which is in good agreement with previously published data ( 12). A first protonation of compound I could lead to structures Ib, Id, Ic, or If; loss of water from I