Pharmacokinetics, N1-glucuronidation and N4-acetylation of sulfadimethoxine in man
β Scribed by Vree, T. B. ;Beneken Kolmer, E. W. J. ;Martea, M. ;Bosch, R. ;Hekster, Y. A. ;Shimoda, M.
- Publisher
- Springer
- Year
- 1990
- Tongue
- Dutch
- Weight
- 948 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1573-739X
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## Abstract __N__βacetyltransferase 1 (NAT1) and 2 (NAT2) enzymes catalyzing both deactivation (__N__βacetylation) and activation (__O__βacetylation) of arylamine carcinogens such as 4βaminobiphenyl (ABP) were investigated in a Syrian hamster model congenic at the __NAT__2 locus. NAT2 catalytic act