Pharmacokinetics of intramuscular nicomorphine and its metabolites in man

✍ Scribed by P. M. Koopman-Kimenai; T. B. Vree; L. H. D. J. Booij; R. Dirksen; G. M. M. Nijhuis

• Publisher: Springer
• Year: 1991
• Tongue: English
• Weight: 352 KB
• Volume: 41
• Category: Article
• ISSN: 0031-6970
• DOI: 10.1007/bf00314971

✦ Synopsis

After i.m. injection nicomorphine is relatively slowly absorbed from the muscular depot and is found in the serum for approximately 1 h. The rate of absorption differs between patients and governs the overall pharmacokinetic profile of the compound. The relative AUCs were nicomorphine 18%, 6-nicotinoylmorphine 17%, and morphine 65%. Nicomorphine and 6-nicotinoylmorphine have significantly higher AUCs after i.m. injection than after i.v. injection, while the AUC of morphine and the total AUC show no difference between the two modes of administration.