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High-performance liquid chromatography and preliminary pharmacokinetics of nicomorphine and its metabolites 3-nicotinoyl and 6-nicotinoylmorphine and morphine

โœ Scribed by P.M. Koopman-Kimenai; T.B. Vree; M.W. Cress-Tijhuis; L.H.D.J. Booy; G. Drijkoningen


Publisher
Elsevier Science
Year
1987
Weight
381 KB
Volume
416
Category
Article
ISSN
0378-4347

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Encainide (ENC) and its metabolites O-demethylencainide (ODE), 3-methoxy-O-demethylencainide (MODE), N-demethylencainide (NDE) and bis-N,O-demethylencainide (NODE) have been measured by two HPLC procedures. The method of Mayol using a mu Porasil column with ethanol-water-methanesulphonic acid as mob