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Pharmacokinetics of antipyrine, warfarin and paracetamol in the brushtail possum

✍ Scribed by C. T. Eason; G. R. G. Wright; R. Gooneratne

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
61 KB
Volume
19
Category
Article
ISSN
0260-437X

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✦ Synopsis

The plasma pharmacokinetics of antipyrine, warfarin and paracetamol have been studied in the Australian brushtail possum (Trichosurus vulpecula). The plasma elimination half-lives (t1/2) were 1.2 h for antipyrine, 11.9 h for warfarin and 5.2-12.9 h for paracetamol. Our data indicate that the clearance of these three xenobiotics in the possum is similar to that reported in eutherian mammals. There was no dose-dependent increase in paracetamol plasma t1/2 over the dose range 100-1000 mg kg(-1), indicating a lack of capacity saturation. This observation may in part explain the unusual resistance of the possum to the hepatotoxic effect of high doses of paracetamol.

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