The influence of vitamin C on antipyrine pharmacokinetics in elderly men

✍ Scribed by James Blanchard; Ramanuj Achari; Gail G. Harrison; Kenneth A. Conrad

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 608 KB
• Volume: 5
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bdd.2510050107

✦ Synopsis

The influence of vitamin C on the pharmacokinetics of antipyrine was investigated in eleven elderly men aged 65-74. Antipyrine (15 mg kgl) was administered intravenously on three separate occasions over a 7-week period: (a) before dietary vitamin C restriction, (b) after approximately 5 weeks of dietary vitamin C restriction, and (c) after 2 weeks of vitamin C supplementation (500 mg orally twice daily). The mean plasma and leucocyte vitamin C levels ( & S.D.) before vitamin C restriction were 1.26 f 0.3 1 mg dl -' and 26.6 k6.7 pg lo-' leucocytes, respectively. These values decreased and then increased significantly following vitamin C restriction and supplementation, respectively. The mean plasma half-life of antipyrine was 10.2 h and the mean plasma clearance was 2.561 h-1.73 m-' before vitamin C restriction. No significant changes in the clearance, volume of distribution, or half-life of antipyrine occurred during the study, indicating that short-term alterations in vitamin C intake do not affect the pharmacokinetics of antipyrine in elderly males.