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Effect of zixoryn on the pharmacokinetics of antipyrine in intact and sensitized guinea pigs

✍ Scribed by T. G. Khlopushina; A. V. Krinskaya; L. P. Kovalenko; V. P. Zherdev; A. V. Val'dman

Publisher
Springer US
Year
1991
Tongue
English
Weight
226 KB
Volume
112
Category
Article
ISSN
0007-4888

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The effect of itraconazole (ITZ) on the pharmacokinetics of digoxin (DGX) was investigated in guinea pigs. The plasma concentrations of DGX in guinea pigs following treatment with ITZ (20 mg/kg intraperitoneally (i.p.)) after intravenous (i.v.) administration of DGX (0.125 mg/kg) were significantly